Julio Scharfstein Selected Research

cruzipain

1/2011	Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways.
7/2009	Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research.
8/2008	Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway.
1/2008	Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi.
11/2006	Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.
7/2002	Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection.

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Julio Scharfstein Research Topics

Disease

21	Infections 01/2018 - 05/2002
15	Inflammation (Inflammations) 01/2022 - 06/2003
9	Edema (Dropsy) 01/2020 - 01/2003
7	Chagas Disease (American Trypanosomiasis) 10/2014 - 07/2002
2	Fibrosis (Cirrhosis) 01/2017 - 01/2011
2	Myocarditis (Carditis) 01/2017 - 01/2012
2	Visceral Leishmaniasis (Kala Azar) 11/2012 - 01/2006
1	COVID-19 01/2021
1	Peritonitis 01/2021
1	Cytokine Release Syndrome 01/2020
1	Thromboinflammation 01/2020
1	Ischemic Stroke 01/2019
1	Cerebral Malaria 01/2019
1	Thrombosis (Thrombus) 01/2017
1	Communicable Diseases (Infectious Diseases) 01/2012
1	Arbovirus Infections 01/2012
1	Alphavirus Infections 01/2012
1	Chronic Periodontitis 09/2009
1	Periodontitis 09/2009
1	Gingivitis 09/2009
1	Emphysema 05/2007
1	Neoplasms (Cancer) 05/2007
1	Rheumatoid Arthritis 05/2007
1	Osteoporosis 05/2007
1	Cardiomyopathies (Cardiomyopathy) 12/2005
1	Chronic Disease (Chronic Diseases) 12/2005
1	Heart Diseases (Heart Disease) 01/2003
1	Persistent Infection 07/2002

Drug/Important Bio-Agent (IBA)

14	KininsIBA 01/2019 - 01/2003
12	BradykininIBA 01/2021 - 05/2003
7	Cysteine Proteases (Cysteine Protease)IBA 09/2009 - 01/2006
6	cruzipainIBA 01/2011 - 07/2002
5	Peptides (Polypeptides)IBA 01/2018 - 05/2003
5	2,5-dichloro-4-bromophenol (B 2)IBA 03/2012 - 11/2006
4	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2018 - 01/2003
4	Bradykinin B2 ReceptorIBA 01/2018 - 11/2006
4	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 01/2006
4	Kininogens (Kininogen)IBA 09/2009 - 01/2006
3	Pharmaceutical PreparationsIBA 01/2021 - 05/2002
3	CytokinesIBA 01/2020 - 07/2002
3	Bradykinin Receptors (Bradykinin Receptor)IBA 01/2019 - 01/2011
3	Endothelin-1 (Endothelin 1)IBA 01/2018 - 05/2003
3	LigandsIBA 01/2017 - 07/2009
3	Endothelins (Endothelin)IBA 01/2017 - 01/2011
3	GTP-Binding Proteins (G-Protein)IBA 11/2012 - 01/2011
2	ChemokinesIBA 01/2020 - 06/2009
2	FibrinIBA 01/2020 - 01/2017
2	EnzymesIBA 01/2019 - 08/2008
2	Endothelin Receptors (Endothelin Receptor)IBA 01/2018 - 01/2012
2	carboxypeptidase MIBA 01/2017 - 01/2011
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 11/2007
2	Factor XII (Hageman Factor)IBA 01/2017 - 01/2017
2	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)IBA 01/2017 - 01/2012
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2014 - 01/2003
2	CXC ChemokinesIBA 01/2012 - 06/2009
2	MucinsIBA 07/2009 - 11/2006
2	icatibantIBA 06/2009 - 01/2006
1	Green Fluorescent ProteinsIBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	Dietary Fiber FDA Link 01/2021
1	InflammasomesIBA 01/2021
1	Oxygen (Dioxygen)IBA 01/2021
1	Conditioned Culture MediaIBA 01/2019
1	HMGB1 Protein (HMG1)IBA 01/2018
1	Arginine (L-Arginine)FDA Link 01/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017
1	Plasma KallikreinIBA 01/2017
1	Tissue Kallikreins (Tissue Kallikrein)IBA 01/2017
1	PolyphosphatesIBA 01/2017
1	CyclodextrinsIBA 03/2012
1	ThapsigarginIBA 03/2012
1	CholesterolIBA 03/2012
1	Verapamil (Calan)FDA LinkGeneric 03/2012
1	CeramidesIBA 01/2012
1	Blood Proteins (Serum Proteins)IBA 01/2012
1	Gingipain Cysteine EndopeptidasesIBA 09/2009
1	LipidsIBA 07/2009
1	trans-sialidaseIBA 07/2009
1	reparixinIBA 06/2009
1	Interferon-gamma (Interferon, gamma)IBA 08/2008
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2008
1	Interleukin-12 (IL 12)IBA 11/2006
1	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 11/2006
1	PapainIBA 06/2006
1	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA 01/2006
1	Vasodilator Agents (Vasodilators)IBA 05/2003
1	Vasoconstrictor AgentsIBA 05/2003
1	LipopolysaccharidesIBA 01/2003
1	Captopril (Capoten)FDA LinkGeneric 01/2003
1	Interleukin-4 (Interleukin 4)IBA 07/2002
1	Secretory Immunoglobulin A (SIgA)IBA 07/2002
1	Immunoglobulin G (IgG)IBA 07/2002
1	congopainIBA 05/2002
1	AntibodiesIBA 05/2002

Therapy/Procedure

1	Denervation 12/2005
1	Aftercare (After-Treatment) 01/2003